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The Philadelphia Eagles begin the 2025 season as heavy favorites to win their season opener Thursday night, but oddsmakers see significant threats in their pursuit of back-to-back Super Bowl titles.

The Buffalo Bills and Baltimore Ravens are the co-Super Bowl favorites at +600 at DraftKings, slightly ahead of the Eagles at +700. The Kansas City Chiefs are next at +850, with no other team having shorter odds than the Green Bay Packers at +1200.

Meanwhile, BetRivers is offering the Ravens and Eagles as +650 co-favorites, followed by the Bills (+700), Chiefs (+800) and the Packers (+1300) along with the Detroit Lions.

The New Orleans Saints are the biggest longshot at both books -- +30000 at BetRivers and +5000 at DraftKings.

Philadelphia is considered to have a smoother path to the Super Bowl than its AFC counterparts. The Eagles are +350 to win the NFC title at DraftKings, ahead of the Packers (+600) and Lions (+650).

The Bills and Ravens are the co-+330 favorites in the AFC, followed by the Chiefs at +400. That trio is well ahead of the pack, with the Denver Broncos owning the fourth shortest AFC title odds at +1100.

Ravens quarterback Lamar Jackson opens the season as the +550 favorite to win Most Valuable Player honors, ahead of Bills reigning league MVP Josh Allen and Cincinnati Bengals quarterback Joe Burrow at +600. The shortest non-quarterback odds belong to Eagles running back Saquon Barkley at +6000.

Las Vegas running back Ashton Jeanty begins the season as the +275 offensive rookie of the year favorite ahead of No. 1 overall pick Cam Ward. The Tennessee Titans quarterback is being offered at +350, followed by Los Angeles Chargers running back Omarion Hampton at +850 and Jacksonville Jaguars dual threat Travis Hunter at +1000.

The shortest defensive rookie of the year odds belong to New York Giants pass rusher Abdul Carter at +225. He's well ahead of a trio at +1200 that includes San Francisco pass rusher Mykel Williams, Ravens linebacker Mike Green and Atlanta Falcons pass rusher Jalon Walker.

--Field Level Media